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Direxion Daily S&P Biotech Bull 3X Shares

Filed by Direxion Shares ETF Trust. What this fund reported holding in its latest quarterly NPORT-P. Positions are ordered by share of the fund rather than by size, because that is what separates a conviction from a rounding error.

Positions
42
matched to a ticker
Fund size
$668.4M
the filing's own figure
Matched value
$132.4M
of the positions below
As of
2026-07-31
S000049373

What it holds

Largest share of the fund first.

Company% of fundValue
TWSTTwist Bioscience Corp0.92%$4.6M
PRAXPraxis Precision Medicines Inc0.87%$4.3M
REGNRegeneron Pharmaceuticals Inc0.87%$4.3M
COGTCogent Biosciences Inc0.85%$4.2M
NTRANatera Inc0.84%$4.2M
ARWRArrowhead Pharmaceuticals Inc0.82%$4M
RLAYRelay Therapeutics Inc0.81%$4M
MRNAModerna Inc0.81%$4M
PCVXVaxcyte Inc0.81%$4M
BBIOBridgeBio Pharma Inc0.81%$4M
HALOHalozyme Therapeutics Inc0.80%$4M
CYTKCytokinetics Inc0.78%$3.9M
AMGNAmgen Inc0.78%$3.8M
INCYIncyte Corp0.77%$3.8M
ABBVAbbVie Inc0.76%$3.8M
VRTXVertex Pharmaceuticals Inc0.75%$3.7M
KRYSKrystal Biotech Inc0.75%$3.7M
INSMInsmed Inc0.73%$3.6M
GILDGilead Sciences, Inc0.73%$3.6M
BMRNBioMarin Pharmaceutical Inc0.73%$3.6M
BIIBBiogen Inc0.71%$3.5M
NBIXNeurocrine Biosciences Inc0.71%$3.5M
ACADACADIA Pharmaceuticals Inc0.71%$3.5M
EXELExelixis Inc0.69%$3.4M
MDGLMadrigal Pharmaceuticals Inc0.68%$3.3M
UTHRUnited Therapeutics Corp0.65%$3.2M
RAREUltragenyx Pharmaceutical Inc0.63%$3.1M
IBRXImmunitybio Inc0.61%$3M
BCRXBioCryst Pharmaceuticals Inc0.59%$2.9M
ARQTArcutis Biotherapeutics Inc0.54%$2.7M
IONSIonis Pharmaceuticals Inc0.48%$2.4M
ALNYAlnylam Pharmaceuticals Inc0.48%$2.4M
VCYTVeracyte Inc0.48%$2.3M
SRPTSarepta Therapeutics Inc0.45%$2.2M
KODKodiak Sciences Inc0.43%$2.1M
NTLAIntellia Therapeutics Inc0.42%$2.1M
AGIOAgios Pharmaceuticals Inc0.41%$2M
NVAXNovavax Inc0.38%$1.9M
CDNACareDx Inc0.34%$1.7M
KURAKura Oncology Inc0.19%$941.5K
OCGNOcugen Inc0.12%$584.6K
EBSEmergent BioSolutions Inc0.08%$418.6K

Source: NPORT-P filings, via EDGAR. Positions arrive by CUSIP, and only a CUSIP verified against a ticker is kept — so this is what we could match, not everything the fund holds, and the matched value is therefore below the fund's own size. A balance is shares where the filing says `NS` and a principal amount where it says `PA`, which is why it is not labelled shares in both cases.

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